Hematopoiese

Interesse da Investigação

Hematopoietic differentiation
1) The role of 3D genomic organization as an epigenetic mechanism for the regulation of gene expression during hematopoietic differentiation
2) Cell-fate decision genes in hematopoietic differentiation.

Publicações

Alcobia, I., Quina, A.S., Neves, H., Clode, N. and Parreira, L. (2003). The spatial organization of centromeric heterochromatin during normal human lymphopoiesis: evidence for ontogenically determined spatial patterns. Experimental Cell Research 290 :358-369

Parreira, L., Neves, H., Simões, S. (2003). Notch and Lymphopoiesis. A view from the microenvironment. Seminars in Immunology 15 :81-89

Jaleco, A.C., Neves, H., Hooijberg, E., Gameiro, P., Clode, N., Haury, M., Henrique, D., Parreira, L. (2001). Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. Journal of Experimental Medicine 194 :991-1001

Alcobia, I., Dilão, R. and Parreira, L. (2000). Spatial associations of centromeres in the nuclei of hematopoietic cells: evidence for cell-type specific organizational patterns. Blood 95 :1608-1615

Neves, H., Ramos, C., Gomes da Silva, M., Parreira, A. and Parreira, L. (1999). The nuclear topography of ABL, BCR, PML and RARa genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation. Blood 93 :1197-1207

Parreira, L., Telhada, M., Ramos, C., Hernandez, R., Neves, H., Carmo-Fonseca, M. (1997). The spatial distribution of human immunoglobulin genes within the nucleus: evidence for gene topography independent of cell type and transcriptional activity. Human Genetics 100 :588-594

Carmo-Fonseca, M., Cunha, C., Custódio, N., Carvalho, C., Jordan, P., Ferreira, J., Parreira, L. () . :. (1996). The topography of chromosome and genes in the nucleus. Exp Cell Res 229 :247

Carvalho, C., Telhada, M., Carmo-Fonseca, M. and Parreira, L. (1995). In situ visualization of immunoglobulin genes in normal and malignant lymphoid cells. J Mol Pathol. 48 :M158-M164

Telhada, M., Carvalho, C., Carmo-Fonseca, M. and Parreira, L. (1995). Influence of transcription and replication on the in situ resolution of immunoglobulin heavy-chain constant region genes. An interphase cytogenetics analysis. Human Genetics 96 :552-561